2-Amino-3-methylphenol

4920-77-8

2835-97-4

The general procedure for the synthesis of 2-amino-3-methylphenol from 2-nitro-3-methylphenol was as follows: 3-methyl-2-nitrophenol (1.0 g, 6.53 mmol) was dissolved in methanol (10 mL) at 23 °C, and Pd/C catalyst (10 wt%, 400 mg) was added. The reaction mixture was deoxygenated under vacuum and then hydrogenated with a hydrogen balloon. After the reaction was carried out under stirring for 5 h, the reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with methanol (100 mL). The combined filtrates were concentrated under vacuum to afford the target product 2-amino-3-methylphenol (803 mg, 100% yield).