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Quetiapine

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Quetiapine Basic information
Quetiapine Chemical Properties
  • Melting point:172-173 °C
  • Boiling point:556.5±60.0 °C(Predicted)
  • Density 1.27±0.1 g/cm3(Predicted)
  • pka14.41±0.10(Predicted)
  • CAS DataBase Reference111974-69-7(CAS DataBase Reference)
Safety Information
Quetiapine Usage And Synthesis
  • Usesantiviral
  • UsesLabelled Quetiapine (Q510000). Used as an antipsychotic.
  • brand nameSeroquel (AstraZeneca).
  • General DescriptionQuetiapine, 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol fumarate (2:1,salt) (Seroquel), is a white to off-white crystalline powderthat is moderately water soluble. Quetiapine is rapidly absorbed,and peak plasma levels occur 1 to 2 hours after administration.Food does not appreciably affect the absorptionof quetiapine. The compound is 83% bound to plasma proteinsand it has a mean elimination half-life of 7 hours.Administration of a single dose of 14C-quetiapine showedthat only 1% of the drug was excreted unchanged, with 73%excreted into the urine and approximately 30% excreted inthe feces.Numerous metabolites of quetiapine are known,and the sulfoxide metabolite represents the major metabolitepresent in plasma. This metabolite is pharmacologicallyinactive. The remaining metabolites represent only5% of the total radioactivity found in plasma. The 7-hydroxyand the 7-hydroxy-N-desalkyl are active metabolites, but because of their low concentrations in plasma are not thoughtto contribute to the overall effects of quetiapine.
    Common side effects associated with quetiapine therapyare orthostatic hypotension and somnolence. These effects are presumably caused by -adrenergic and histamine H1 receptorblockade, respectively. As with other atypical antipsychotics,patients treated with quetiapine should be monitoredfor hyperglycemic symptoms. Also, children and adolescentswith major depressive disorder may experience an increase intheir depression or suicidal tendencies.typical antipsychotics such as chlorpromazine.This findingmay explain the lack of EPS associated with quetiapine.
Quetiapine(111974-69-7)Related Product Information
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