CPD2802
CPD2802 性质
| 熔点 | 238 °C |
|---|---|
| 沸点 | 843.3±65.0 °C(Predicted) |
| 密度 | 1.495±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO:130.0(最大浓度 mg/mL);283.9(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.88±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
CPD2802 用途与合成方法
IC50: 52 nM (liver Glycogen phosphorylase), 352 nM (Muscle Glycogen phosphorylase), 150 nM (Barin Glycogen phosphorylase)
Ingliforib is a glycogen phosphorylase inhibitor, and inhibits the myocardial GP isoforms (muscle and brain) with IC 50 s of 352 and 150 nM, respectively, also a potent inhibitor of the liver isoform (IC 50 of 52 nM). Ingliforib (0.1, 1, 10 μM) dose-dependently reduces infarct size in the isolated rabbit hearts.
Ingliforib (15 mg/kg) potently reduces infarct size by 52%, and decreases plasma glucose and lactate concentrations in openchest anesthetized rabbits. Ingliforib (15 mg/kg) also inhibits myocardial glycogen phosphorylase a (GPa) and total glycogen phosphorylase (GP) activity in anesthetized rabbits.
CPD2802 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-19396 | 1 mg | 1180 | ||
| 2024-04-30 | HY-19396 | CPD2802 | 186392-65-4 | 5mg | 2380 |
