Praziquantel-d11

Praziquantel-d₁₁ is intended for use as an internal standard for the quantification of praziquantel by GC- or LC-MS. Praziquantel is an anthelmintic agent. It is lethal to S. mansoni schistosomula and adults (LC₅₀s = 0.68 and 0.03 mg/ml, respectively). Praziquantel (172 and 592 mg/kg) reduces worm burden in a mouse model of S. mansoni infection. Formulations containing praziquantel have been used in the treatment of schistosomiasis.

Off-White Solid

Labelled Praziquantel (P702095). Anthelmintic, effective against flatworms.

As Labelled Praziquantel (P702095), Praziquantel-d11 can beused as Anthelmintic, effective against flatworms.

Praziquantel-d11 can be intended for use as an internal standard for the quantification of Praziquantel by GC- or LC-mass spectrometry.

Schistosome

[1] COOK G C. Anthelminthic agents: some recent developments and their clinical application.[J]. Postgraduate Medical Journal, 1991, 67 783: 16-22. DOI: 10.1136/pgmj.67.783.16
[2] PIERO OLLIARO J K Petra Delgado Romero. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer).[J]. The Journal of antimicrobial chemotherapy, 2014: 863-870. DOI: 10.1093/jac/dkt491