盐酸青藤碱
![盐酸青藤碱 结构式](https://img.chemicalbook.com/CAS/GIF/6080-33-7.gif)
盐酸青藤碱 性质
熔点 | 231.0 to 235.0 °C |
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储存条件 | Inert atmosphere,2-8°C |
溶解度 | 在水中的溶解度为20mg/mL,澄清 |
形态 | 粉末 |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D -70 to -90°, c = 1 in H2O |
水溶解性 | Soluble to 100 mM in water |
盐酸青藤碱 用途与合成方法
NF-κB
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μ-opioid receptor
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Cell viability is gradually decreased with increasing Sinomenine hydrochloride concentration. The migration ability of MDA-MB-231 cells is significantly weakened by 0.25, 0.5, and 1 mM of Sinomenine hydrochloride treatment. The wound-healing assay reveals that 0.25 and 0.5 mM Sinomenine hydrochloride significantly suppress the healing of the wound. When the MDA-MB-231 cells are treated with 0.5 mM Sinomenine hydrochloride, the healing progress is about 50%, but in the group treated with 0.25 mM Sinomenine hydrochloride and the untreated control, the healing is about 80% and nearly 95%, respectively. The IB assay following inhibitor of NF-κB (IκB) antibody IP shows that the binding of NF-κB to IκB is inhibited by Sinomenine hydrochloride treatment in a dose-dependent manne.
Sinomenine hydrochloride (i.p.) produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. At 80 mg/kg, Sinomenine hydrochloride is mildly sedative in rats. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test.
药理药效:具有祛风除湿,活血通络,利尿消肿的作用。
盐酸青藤碱 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2025-02-05 | HY-15122A | 盐酸青藤碱 | 6080-33-7 | 100mg | 550 |
2025-02-05 | HY-15122A | 盐酸青藤碱 | 6080-33-7 | 10mM * 1mLin DMSO | 605 |