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Triprolidine hydrochloride

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Triprolidine hydrochloride Basic information
Triprolidine hydrochloride Chemical Properties
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS UT7658000
  • HS Code 2933399090
MSDS
Triprolidine hydrochloride Usage And Synthesis
  • Chemical PropertiesTRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.
  • UsesTRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
  • Usesanticholinergic (opthalmic)
  • DefinitionTRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.
  • brand nameActidil (GlaxoSmithKline); Myidyl (USl).
  • General DescriptionTriprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.
    The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
  • General DescriptionOdorless white crystalline powder. Bitter taste.
  • Air & Water ReactionsWater soluble.
  • Reactivity ProfileTriprolidine hydrochloride discolors on exposure to light.
  • Health HazardSYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.
  • Fire HazardFlash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.
  • Biological ActivityPotent H 1 receptor antagonist.
Triprolidine hydrochloride(6138-79-0)Related Product Information
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