Lysicamine

This oxodibenzoquinoline alkaloid occurs in Lysichiton camtschatcense Schott var. japonicum Makino. Being a fully conjugated molecule, the alkaloid is coloured, yielding yellow needles when crystallized from EtOH. The ultraviolet spectrum in neutral solution (EtOH) has absorption maxima at 235, 270, 307 and 400 mil. In acid solution (EtOH-O.l N/HCl), the absorption maxima occur at 249,276,306 and 453 mil. The structure has been established by synthesis as 1 :2-dimethoxy-7-oxodibenzo[de, gj quinoline.

Lyscamine has shown to have cytotoxicity against various human cancer cells. It can also be enriched using response surface method and adsorption on macroporous resin.

ChEBI: A natural product found in Annona glabra.

Katsui et al., Tetrahedron Lett., 6257 (1966)