1-hydrazino-3-(methylthio)propan-2-ol

White powder

1-hydrazino-3-(methylthio)propan-2-ol, also known as 3-methylmercapto-2-hydroxy-propyl hydrazine, is an important organic reagent that can be used as a building block for the synthesis of many organic compounds. It can be used to synthesize N-amino-5-methylmercapto-methyl-2-oxazolidinone which is an intermediate of nifuratel.

Add 226.25g hydrazine hydrate to 1000ml reaction flask, heat to 90℃, and add 104.17g of glycidyl ether under stirring. The temperature of the reaction system was controlled at 90℃, and then the excess hydrazine hydrate was concentrated under reduced pressure to obtain 120.10g thick colorless liquid. The purity of the gas phase was 96.8%, namely 1-hydrazino-3-(methylthio)propan-2-ol, and the yield was 88.30%.