The elimination of Sulfaclozine in the three systems: UV/TiO
2
, UV/K
2
S
2
O
8
, and UV/TiO
2
/K
2
S
2
O
8
. Sulfaclozine is weakly adsorbed on the surface of TiO
2
at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO
2
, UV/K
2
S
2
O
8
, and UV/TiO
2
/K
2
S
2
O
8
in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of
•
OH and SO
4
•−
radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.
Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.
Animal Model:
14 male broiler chickens (30-day-old)
Dosage:
60 mg/kg
Administration:
Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result:
Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
