磺胺氯吡嗪钠

生物活性靶点体外研究体内研究磺胺氯吡嗪钠试剂级价格

磺胺氯吡嗪钠

CAS号:102-65-8
英文名:N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO
中文名:磺胺氯吡嗪钠
CBNumber:CB5854974
分子式:C10H9ClN4O2S
分子量:284.72
MOL File:102-65-8.mol

磺胺氯吡嗪钠化学性质

熔点 :234.8-235.4 °C
沸点 :495.7±55.0 °C(Predicted)
密度 :1.588±0.06 g/cm3(Predicted)
储存条件 :2-8°C(protect from light)
溶解度 :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
形态 :Solid
酸度系数(pKa) :4.83±0.10(Predicted)
颜色 :White to Off-White

磺胺氯吡嗪钠性质、用途与生产工艺

生物活性 Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药，用于球虫病的研究。
靶点

Bacterial; Parasite
体外研究

The elimination of Sulfaclozine in the three systems: UV/TiO ₂ , UV/K ₂ S ₂ O ₈ , and UV/TiO ₂ /K ₂ S ₂ O ₈ . Sulfaclozine is weakly adsorbed on the surface of TiO ₂ at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO ₂ , UV/K ₂ S ₂ O ₈ , and UV/TiO ₂ /K ₂ S ₂ O ₈ in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of ^• OH and SO ₄ ^•− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals.

体内研究

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections.

Animal Model:	14 male broiler chickens (30-day-old)
Dosage:	60 mg/kg
Administration:	Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result:	Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.

用途磺胺氯吡嗪钠为抗球虫的专用磺胺药，广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成，从而抑制细菌和球虫的生长繁殖。本品对家禽球虫的作用特点与磺胺喹沙啉相似，但具更强的抗菌作用，甚至可治疗禽霍乱及鸡伤寒因此最适合球虫病爆发时治疗用。
用途本品为抗球虫的专用磺胺药，广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成，从而抑制细菌和球虫的生长繁殖。本品对家禽球虫的作用特点与磺胺喹沙啉相似，但具更强的抗菌作用，甚至可治疗禽霍乱及鸡伤寒因此最适合球虫病爆发时治疗用。
用途磺胺类抗菌药，用于禽畜大肠杆菌和巴式杆菌感染，与甲氧苄啶与蔗糖配置而成复方磺胺氯哒嗪钠盐效果更加，对磺胺类药过敏者忌用，肾功能减退者慎用。