tert-Butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate

509073-62-5

350684-49-0

General procedure for the synthesis of tert-butyl 4-(4-aminobenzoyl)tetrahydro-1(2H)-pyrazinecarboxylate from tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate: a mixture of tert-butyl 4-(4-nitrobenzoyl)piperazine-1-carboxylate (20 g, 60 mmol) with 10% Pd/C (4 g) in methanol (600 mL) was subjected to hydrogen (1 atm) atmosphere and the reaction was stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to afford 18 g of tert-butyl 4-(4-aminobenzoyl)piperazine-1-carboxylate as a white solid in 100% yield.