MSA-2

MSA-2 was identified in a phenotypic screen for a chemical inducer of interferon beta secretion. In cell-free assays, MSA-2 binds to human and mouse STING. In tumor-bearing mice, MSA-2 induced elevated interferon-beta in plasma and tumors through two routes of administration.

MSA-2 is an oral non-nucleotide STING agonist with EC50 of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively.

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