| 名称 | MSA-2 |
| 描述 | MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3] |
| 动物实验 | Animal Model was MC38 tumor-bearing C57BL6 mice,and The dosage was 60 mg/kg.Administration was P.o.;s.c (50 mg/kg);single dose[1]
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| 体外活性 | METHODS: PK-15 cells were treated with MSA-2 at concentrations of 20, 30, 40 and 50 μM for 24 hours and then infected with SVV at 10 MOI. SVV RNA levels in treated cells were detected by RT-qPCR at 24 h post-infection (hpi).
RESULTS Viral RNA levels in MSA-2-treated cells were significantly reduced in a dose-dependent manner. [2] |
| 体内活性 | METHODS: The EMT-6 mouse model was treated with MSA-2 (50 mg/kg, orally), and the changes in intratumoral cytokines and chemokines after MSA-2 treatment in vivo were explored.
RESULTS IFN-β, IL-6, TNF-α, IFN-γ, and classical activation-associated chemokines including CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL9, and CXCL10 were significantly upregulated in EMT-6 tissues. [1]
METHODS: MSA-2 was orally administered at a single dose of 50 mg/kg to mice bearing U14 and TC-1 cervical tumor models. Mice were treated with 5 mg/kg of anti-PD-1 every other day for a total of 3 treatments. Tumor volume was assessed every other day.
RESULTS The tumor volume of mice was significantly reduced. [2] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (169.88 mM), Sonication and heating to 80℃ are recommended.
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| 关键字 | interferon-β | Inhibitor | TMEM173 | MSA 2 | ERIS | MPYS | immunity | secretion | tumor | Stimulator of Interferon Genes | MC38 | MSA2 | STING | TNF-α | MITA | inhibit | MSA-2 |
| 相关产品 | SR-717 | ChX710 | SN-008 | Vadimezan | Dazostinag disodium | diABZI STING agonist-1 | C-176 | Cridanimod | CCCP | diABZI STING agonist-1 trihydrochloride | STING activator Compound 53 | C-178 |
| 相关库 | 经典已知活性库 | NO PAINS 化合物库 | 口服活性化合物库 | 肿瘤免疫治疗小分子化合物库 | 已知活性化合物库 | 共价抑制剂库 | 抗癌化合物库 | 抗癌活性化合物库 |
United States
