| Name | MSA-2 |
| Description | MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3] |
| Animal Research | Animal Model was MC38 tumor-bearing C57BL6 mice,and The dosage was 60 mg/kg.Administration was P.o.;s.c (50 mg/kg);single dose[1]
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| In vitro | METHODS: PK-15 cells were treated with MSA-2 at concentrations of 20, 30, 40 and 50 μM for 24 hours and then infected with SVV at 10 MOI. SVV RNA levels in treated cells were detected by RT-qPCR at 24 h post-infection (hpi).
RESULTS Viral RNA levels in MSA-2-treated cells were significantly reduced in a dose-dependent manner. [2] |
| In vivo | METHODS: The EMT-6 mouse model was treated with MSA-2 (50 mg/kg, orally), and the changes in intratumoral cytokines and chemokines after MSA-2 treatment in vivo were explored.
RESULTS IFN-β, IL-6, TNF-α, IFN-γ, and classical activation-associated chemokines including CCL2, CCL3, CCL4, CCL5, CXCL1, CXCL9, and CXCL10 were significantly upregulated in EMT-6 tissues. [1]
METHODS: MSA-2 was orally administered at a single dose of 50 mg/kg to mice bearing U14 and TC-1 cervical tumor models. Mice were treated with 5 mg/kg of anti-PD-1 every other day for a total of 3 treatments. Tumor volume was assessed every other day.
RESULTS The tumor volume of mice was significantly reduced. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 255 mg/mL (866.4 mM), Sonication and heating to 80℃ are recommended.
0.5% CMC-Na : 12.5 mg/mL (42.47 mM), Suspension.
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| Keywords | tumor | TNF-α | TMEM173 | STING | Stimulator of Interferon Genes | secretion | MSA-2 | MSA2 | MSA 2 | MPYS | MITA | MC38 | interferon-β | Inhibitor | inhibit | immunity | ERIS |
| Inhibitors Related | 2',3'-cGAMP sodium | SR-717 | H-151 | ChX710 | SN-008 | Vadimezan | Dazostinag disodium | C-176 | Cridanimod | CCCP | diABZI STING agonist-1 trihydrochloride | C-178 |
| Related Compound Libraries | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | NO PAINS Compound Library | Orally Active Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
