圣草酚
圣草酚 性质
| 熔点 | 270°C |
|---|---|
| 沸点 | 625.2±55.0 °C(Predicted) |
| 密度 | 1.586±0.06 g/cm3(Predicted) |
| FEMA | 4715 | 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-CHROMANON |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（非常轻微） |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.49±0.40(Predicted) |
| 颜色 | 白色至浅棕色 |
| 水溶解性 | 70mg/L(20 ºC) |
| JECFA Number | 2172 |
| BRN | 5104930 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1 |
| InChIKey | SBHXYTNGIZCORC-ZDUSSCGKSA-N |
| SMILES | Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c3ccc(O)c(O)c3 |
| CAS 数据库 | 552-58-9(CAS DataBase Reference) |
圣草酚 用途与合成方法
圣草酚能抗菌、抗炎，在糖尿病的发病机制中起着至关重要的作用，可以抑制 immunoglobulin E(Ig E)/antigen (Ag)诱导I型过敏反应，同时具有止痛及温热功效。 Eriodictyol 是从中草药中得到的黄酮类，具有抗氧化、抗炎的功效。Eriodictyol 能够诱导 Nrf2 信号通路。Eriodictyol 还是一种流感依赖 RNA 的 RNA 聚合酶抑制剂，IC50 为 18 nM。
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Human Endogenous Metabolite
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Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ 25-35 -induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons.
Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues.
药理药效:抗氧化、抗辐射、降血脂、降血糖。
圣草酚 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-07-06 | 46524 | 圣草酚 | 552-58-9 | 250mg | 2120 |
| 2026-07-06 | S9123 | 圣草酚 | 552-58-9 | 1mg | 1204.79 |
