α-D-Glucose-1,6-bisphosphate (cyclohexyl ammonium salt hydrate)

α-D-Glucose-1,6-bisphosphate is a bis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1 It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2 It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4 α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism.WARNING This product is not for human or veterinary use.

[1] BEITNER R. Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate[J]. International Journal of Biochemistry, 1990, 22 6: Pages 553-557. DOI: 10.1016/0020-711x(90)90030-7
[2] PUSHPA MALIEKAL. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family.[J]. The Journal of Biological Chemistry, 2007, 282 44: 31844-31851. DOI: 10.1074/jbc.m706818200
[3] HANAN M.A. MOUSTAFA  Y. H P Z  Taha I Zaghloul. A simple assay for determining activities of phosphopentomutase from a hyperthermophilic bacterium Thermotoga maritima[J]. Analytical biochemistry, 2016, 501: Pages 75-81. DOI: 10.1016/j.ab.2016.02.013
[4] TIMOTHY D PANOSIAN. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle.[J]. The Journal of Biological Chemistry, 2011, 286 10: 8043-8054. DOI: 10.1074/jbc.m110.201350