UDP-α-D-Glucose (sodium salt hydrate)

UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y₁₄ receptor (EC₅₀ = 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells. It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.

[1] KENNETH A JACOBSON. Development of selective agonists and antagonists of P2Y receptors.[J]. Purinergic Signalling, 2009, 5 1: 75-89. DOI: 10.1007/s11302-008-9106-2
[2] D. LECCA. The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair[J]. PLoS ONE, 2008, 3 1. DOI: 10.1371/journal.pone.0003579