2-庚基-4-羟基喹啉-N-氧化物
2-庚基-4-羟基喹啉-N-氧化物 性质
| 熔点 | 156-157° |
|---|---|
| 沸点 | 445.8±37.0 °C(Predicted) |
| 密度 | 1.09±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 可溶于 DMSO（加热时高达 8 mg/ml）或乙醇（加热时高达 13 mg/ml）。 |
| 酸度系数(pKa) | 1.07±0.40(Predicted) |
| 形态 | 白色至类白色结晶固体。 |
| 颜色 | 白色 |
| 稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达1个月。 |
2-庚基-4-羟基喹啉-N-氧化物 用途与合成方法
| Target | Value |
|
Complex III
(Cell-free assay) | 64 nM(Kd) |
|
NDH-2
(Cell-free assay) | 7.3 μM |
HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including
Yarrowia lipolytica
,
S. cerevisiae
,
Gluconobacter oxydans
,
T. gondii
,
P. falciparum
, and
S. aureus
. HQNO targets the Q-site of NDH-2.
HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E
C. thermarum
NDH-2 variant, respectively to determine IC
50
values. WT NDH-2 has an IC
50
value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC
50
value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC
50
value of 54.3±1.2 μM.
2-庚基-4-羟基喹啉-N-氧化物 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-130055 | 5 mg | 625 | ||
| 2024-01-25 | HY-130055 | 2-庚基-4-羟基喹啉-N-氧化物 | 341-88-8 | 10mg | 1000 |
