U-74389G

Product NameU-74389G
CAS153190-29-5
MFC41H54N6O6
MW726.9
EINECS
MOL File153190-29-5.mol

Chemical Properties

storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	ethanol: soluble20 mg/mL, clear, light yellow
form	White solid.
color	White
Sensitive	Hygroscopic
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	ABCSSKWSUJMJCP-WQDFMEOSSA-N
SMILES	OC(=O)\C=C/C(O)=O.[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)C1=CC[C@]4(C)[C@H](CC[C@@]24[H])C(=O)CN5CCN(CC5)c6cc(nc(n6)N7CCCC7)N8CCCC8

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Description

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

Uses

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.

in vivo

U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change^[2].
U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta^[3].

Animal Model:	Rat model of trinitrobenzenesulfonic acid-induced colitis^[2]
Dosage:	10 mg/kg
Administration:	Intravenous injection; 10 mg/kg; once daily; 6 d
Result:	Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.

Animal Model:	Male Sprague–Dawley rats injected with Lipopolysaccharide^[3]
Dosage:	15 or 30 mg/kg
Administration:	Intravenous injection; 15 or 30 mg/kg
Result:	Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).

References

[1] J. BRAUGHLER. Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.[J]. The Journal of Biological Chemistry, 1987, 27 1: 10438-10440. DOI:10.1016/s0021-9258(18)60979-2
[2] G M CAMPO. Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 1: 333-340.
[3] A.M. PERNA . PROTECTION OF RAT HEART FROM ISCHAEMIA-REPERFUSION INJURY BY THE 21-AMINOSTEROID U-74389G[J]. Pharmacological research, 1996, 34 1: Pages 25-31. DOI:10.1006/phrs.1996.0059

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