U-74389G

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.

1) Braughler et al. (1987) Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation; J. Biol. Chem., 262 10438 2) Campo et al. (1996) Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation; J. Pharmacol. Exp. Ther., 277 333 3) Perna et al. (1996) Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G; Pharmacol. Res., 34 25