Description
U-
74389G is an antioxidant which prevents iron-
dependent lipid peroxidation. It protects against ischemia-
reperfusion injury in animal heart, liver, and kidney models.
Uses
U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.
References
1) Braughler et al. (1987) Novel 21-aminosteroids as potent inhibitors of iron-dependent lipid peroxidation; J. Biol. Chem., 262 10438
2) Campo et al. (1996) Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation; J. Pharmacol. Exp. Ther., 277 333
3) Perna et al. (1996) Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G; Pharmacol. Res., 34 25