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Limaprost is an analog of prostaglandin E₁ (PGE₁) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE₁ as an inhibitor of platelet adhesiveness measured in vitro.¹ 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-methoxy limaprost.

ChEBI: 3-methoxylimaprost is a prostanoid.

1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E₁ derivative, as an antianginal agent Arch. Int. Pharmacodyn. Ther. 247(1),89-102(1980).