Description
Limaprost is an analog of prostaglandin E
1 (PGE
1) with structural modifications intended to give it a prolonged half-
life and greater potency. Limaprost is an inhibitor of ADP and collagen-
induced platelet aggregation and is 10-
1,000 times more potent than PGE
1 as an inhibitor of platelet adhesiveness measured
in vitro.
1 3-
methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-
methoxy limaprost.
References
1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al.
Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent Arch. Int. Pharmacodyn. Ther. 247(1),89-102(1980).
