8-Bromoadenosine-3',5'-cyclic monophosphate sodium salt

Off-white powder

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

• to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
• used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
• in superfusion medium for head kidneys stimulation

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

Cell-permeable cAMP analog; activator of protein kinase A. Also available as part of the PKA Tocriset™ .

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

-20°C (desiccate)