BDZ-g is a potent inhibitor of both the closed-channel and the open-channel conformations of all four homomeric AMPA receptor channels, as well as two GluA2R containing complex AMPA receptor channels.
Uses
BDZ-g is a potent, selective antagonist of AMPA receptor. BDZ-g has the potential for the research of various neurological disorders involving excessive activity of AMPA receptors[1].
References
[1] Wang C, et al. Mechanism and site of inhibition of AMPA receptors: pairing a thiadiazole with a 2,3-benzodiazepine scaffold. ACS Chem Neurosci. 2014;5(2):138-147. DOI:10.1021/cn400193u
