Pharmacological activity investigating:
- The drug effects on metabolization
- In vitro cytochrome P450 activity in microsomes
Analyte for electron-capture gas chromatography procedures
Pharmacological activity investigating:• ;The drug effects on metabolization1• ;In vitro cytochrome P450 activity in microsomes2Analyte for electron-capture gas chromatography procedures3
CYP2C19 metabolite of Mephenytoin
ChEBI: Hydroxymephenytoin is an imidazolidine-2,4-dione.
CYP2C19 metabolite of mephenytoin.
4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized.
