N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl- D-Argininamide-L-cysteine Disulfide is a useful research chemical used in the treatment of chronic kidney disease-mineral and bone disorder.
ChEBI: Etelcalcetide is an oligopeptide.
Etelcalcetide is a calcimimetic agent that allosterically modulates the
calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and
enhances activation of the receptor by extracellular calcium. Activation
of the CaSR on parathyroid chief cells decreases PTH secretion.
Synthetic peptide calcimimetic agent:Treatment of secondary hyperparathyroidism in
patients on haemodialysis
Potentially hazardous interactions with other drugs
Avoid with cinacalcet.
Etelcalcetide is biotransformed in blood by reversible
disulphide exchange with endogenous thiols to
predominantly form conjugate with serum albumin
