4-Cyclopropylbenzaldehyde

1122-91-4

411235-57-9

20034-50-8

Using p-bromobenzaldehyde and cyclopropylboronic acid as starting materials, 4-cyclopropylbenzaldehyde was prepared by reacting 6-(4-bromophenyl)-3-((2-chlorophenyl)thio)-6-(thiophen-3-yl)piperidin-2,4-dione with 6-(4-bromophenyl)-3-((2-chlorophenyl)thio)-6-(thiophen-3-yl)piperidin-2,4-dione with reference to the method of Example 8 Step A. The method was carried out by substituting cyclopropylboronic acid as cyclohex-1-en-1-ylboronic acid. After completion of the reaction, the target product was obtained after post-treatment in 80% yield.