Tos-PEG6-t-Butyl ester

Tos-PEG6-t-Butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Tos-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Alkyl/ether; PEGs

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.