Tos-PEG7-t-butyl ester

Product NameTos-PEG7-t-butyl ester
CAS406213-75-0
MFC26H44O11S
MW564.69
EINECS
MOL File406213-75-0.mol

Chemical Properties

Boiling point	621.1±55.0 °C(Predicted)
Density	1.146±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
form	Liquid
color	Yellow to brown

Usage And Synthesis

Description

Tos-PEG7-t-Butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG6-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6