Tos-PEG9-t-butyl ester

Product NameTos-PEG9-t-butyl ester
CAS1345337-28-1
MFC30H52O13S
MW652.79
EINECS
MOL File1345337-28-1.mol

Chemical Properties

Boiling point	677.8±55.0 °C(Predicted)
Density	1.142±0.06 g/cm3(Predicted)
storage temp.	Store at Room Tem.
solubility	Soluble in DMSO, DCM, DMF

Usage And Synthesis

Description

Tos-PEG9-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6