(5-PyriMidinecarboxylicacid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-(Methylthio)-,ethyl ester)

5909-24-0

115514-77-7

330785-81-4

General procedure for the synthesis of 4-(3-chloro-4-methoxybenzylamino)-2-methylmercapto-5-ethoxycarbonylpyrimidine from 4-chloro-2-methylthiopyrimidine-5-carboxylic acid ethyl ester and 3-chloro-4-methoxybenzylamine: firstly, 3-chloro-4-methoxybenzylamine (45.6 g, 0.27 mol) was dissolved in 180 mL of acetone, followed by triethylamine (40.4 g, 0.4 mol). Next, ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (53.3 g, 0.24 mol) was dissolved in 250 mL of acetone and slowly added dropwise to the above reaction solution. The reaction was carried out at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was poured into an ice-water mixture and extracted with ethyl acetate. The organic phases were combined and washed with 10% aqueous citric acid (250 mL x 3). The organic layer was dried with anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure. Finally, the product was dried under vacuum to give a white solid (86.0 g, 87.0% yield).