3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE

2393-23-9

41965-95-1

General procedure for the synthesis of 3-chloro-4-methoxybenzylamine hydrochloride from 4-methoxybenzylamine: acetic acid (100 ml) was slowly added to 4-methoxybenzylamine (100 g) at 25-30 °C. Subsequently, additional acetic acid (750 ml) was added to the reaction mixture. Sulfonyl chloride (87.84 ml) was slowly added dropwise to the reaction mixture at 20-25 °C and stirred continuously for 6 h at the same temperature. After completion of the reaction, methyl tert-butyl ether (850 ml) was added to the reaction mixture at 25-30 °C. The reaction mixture was cooled to 15-20°C and stirring was continued at this temperature for 1 hour. The precipitated solid product was filtered, washed with methyl tert-butyl ether and dried to give 3-chloro-4-methoxybenzylamine hydrochloride. Yield: 118 g.