Ecopipam (0.003-0.3 mg/kg, a single s.c.) hydrochloride abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats[3].
Ecopipam (10, mg/kg, oral administration) hydrochloride antagonizes Apomorphine-induced stereotypy in rats[4].
Ecopipam (5 and 10 μM, perfusion, 1 μL/min) hydrochloride reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].
| Animal Model: | Male young adult Long-Evans rats injected with Nicotine[3] |
| Dosage: | 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg |
| Administration: | A single s.c. 20 min before Nicotine (0.1 mg/kg) |
| Result: | Dose-dependently reduced pressing on both active and inactive levers. |
