基本属性 生物活性靶点体外研究体内研究 用途与合成方法 101193-62-8 价格(试剂级) 供应商 供应信息

101193-62-8

101193-62-8

中文名称:101193-62-8
英文名称:FK-021
CAS号:101193-62-8
分子式:C17H13N6NaO3
分子量:372.32
EINECS号:
Mol文件:101193-62-8.mol
101193-62-8 结构式

101193-62-8 性质

储存条件 Store at -20°C
溶解度 溶于二甲基亚砜
形态 固体
颜色 浅黄至黄色

101193-62-8 用途与合成方法

Quinotolast sodium (浓度范围为 1-100 μg/mL) 抑制组胺,LTC4 和 PGD2 释放,这种作用具有浓度依赖性。

LTC 4

PGD 2

Histamine

Quinotolast inhibits the release of histamine and the generation of leukotriene (LT) C 4 and prostaglandin (PG) D 2 from dispersed human lung cells. Quinotolast (100 μg/mL) significantly inhibits PGD 2 and LTC 4 release. Quinotolast inhibits PGD 2 release by 100% and LTC 4 release by 54%. The inhibitory effect of Quinotolast on histamine release from dispersed lung cells is largely independent of the preincubation period, no tachyphylaxis being observed. Quinotolast shows a significant inhibition of inflammatory mediators from human dispersed lung cells. Quinotolast also shows strong inhibitory effects on histamine and peptide leukotrienes release from guinea pig lung fragments or mouse cultured mast cells. Quinotolast concentration-dependently inhibits pLTs release from cultured mast cells. The IC 50 value for Quinotolast is 0.72 μg/mL.

Quinotolast potently inhibits such type I allergic reactions as passive cutaneous anaphylaxis (PCA) and anaphylactic bronchoconstriction in rats by both intravenous and oral dosing. When Quinotolast is given i.v. to rats, Quinotolast, dose-dependently inhibits PCA. The doses of Quinotolast required to inhibit the reaction by 50% (ED 50 ) is 0.0063 mg/kg. Given p.o., Quinotolast inhibits the reaction. ED 50 value for Quinotolast is 0.0081 mg/kg. Although almost complete inhibition is observed with Quinotolast at a dose of 0.32 mg/kg, its effect is slightly attenuated at a dose of 1 mg/kg.

101193-62-8 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-U00027 1 mg 2000
2024-11-08 HY-U00027 5 mg 5000

101193-62-8供应商 更多

天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
中文名称:喹托司特钠
英文名称:Quinotolast sodium
CAS:101193-62-8
包装信息:1g
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 Quinotolast sodium
英文名称:Quinotolast sodium
CAS:101193-62-8
包装信息:25mg/RMB 12800;50mg/RMB 16800;100mg/RMB 21500

最新发布供应信息

化合物 Quinotolast sodium|T13855|TargetMol
TargetMol中国(陶术生物) 2024-12-12