5-(N-乙基-N-异丙基)阿米洛利
5-(N-乙基-N-异丙基)阿米洛利 性质
| 熔点 | 202-205 °C(lit.) |
|---|---|
| 密度 | 1.49±0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 可溶于乙腈（轻微加热）、DMSO（轻微）、甲醇（轻微） |
| 酸度系数(pKa) | 8.67±0.46(Predicted) |
| 形态 | 灰白色至黄色固体。 |
| 颜色 | 淡黄色至绿色 |
| 生物来源 | synthetic |
| 稳定性 | 在甲醇中不稳定 |
| InChI | InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20) |
| InChIKey | QDERNBXNXJCIQK-UHFFFAOYSA-N |
| SMILES | C1(C(NC(N)=N)=O)=NC(Cl)=C(N(CC)C(C)C)N=C1N |
| CAS 数据库 | 1154-25-2 |
5-(N-乙基-N-异丙基)阿米洛利 用途与合成方法
IC50: 10.5 μM (TRPP3 channel)
NHE
Macropinocytosis
In the presence of 100 μM EIPA, 10 μM benzamil, and 10 μM phenamil, 45 Ca 2+ uptake decreases from 79±9 to 46±4 (58% remaining), 27±4 (34%), 29±5 (37%), and 38±4 (48%) pmol/oocyte/30 min (n=6, P=0.008), respectively. It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca 2+ -activated TRPP3 channel activation at -50 mV, with IC 50 s of 143±8 (n=36), 10.5±2.2 (n=28), 1.1±0.3 (n=30), and 0.14±0.04 μM (n=25), respectively. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compare with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-37/39 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
5-(N-乙基-N-异丙基)阿米洛利 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-101840 | 5-(N-乙基-N-异丙基)阿米洛利 | 1154-25-2 | 5mg | 500 |
| 2025-12-22 | HY-101840 | 5-(N-乙基-N-异丙基)阿米洛利 | 1154-25-2 | 10mM * 1mLin DMSO | 550 |
