丹酚酸C
丹酚酸C 性质
| 沸点 | 844.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.570 |
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | 溶于甲醇和水 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 2.76±0.10(Predicted) |
| 颜色 | 粘黄色 |
| 主要应用 | food and beverages |
| InChIKey | GCJWPRRNLSHTRY-QKKCHETFNA-N |
| SMILES | C(O)(=O)[C@H](OC(=O)/C=C/C1=C2C(=C(O)C=C1)OC(C1=CC=C(O)C(O)=C1)=C2)CC1=CC=C(O)C(O)=C1 |&1:3,r| |
丹酚酸C 用途与合成方法
|
CYP2C8 4.82 μM (Ki) |
CYP2J2 5.75 μM (Ki) |
Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K i s of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF‑κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells.
Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus.
药理药效:具有一定抗氧化、保护脑组织细胞损伤、保护心脑血管系统和抗HIV作用。
丹酚酸C 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-N0319 | 丹酚酸C | 115841-09-3 | 1 mg | 323 |
| 2025-12-22 | HY-N0319 | 丹酚酸C | 115841-09-3 | 2 mg | 520 |
