丹酚酸C

生物活性靶点体外研究体内研究丹酚酸C 试剂级价格

丹酚酸C

CAS号:115841-09-3
英文名:Salvianolicacid C
中文名:丹酚酸C
CBNumber:CB52106071
分子式:C26H20O10
分子量:492.43
MOL File:115841-09-3.mol

丹酚酸C化学性质

沸点 :844.2±65.0 °C(Predicted)
密度 :1.570
储存条件 :under inert gas (nitrogen or Argon) at 2-8°C
溶解度 :Soluble in methanol and water
形态 :powder
酸度系数(pKa) :2.76±0.10(Predicted)
颜色 :Yellow

丹酚酸C性质、用途与生产工艺

生物活性 Salvianolic acid C 是细胞色素 P4502C8 (CYP2C8) 的非竞争性抑制剂和细胞色素 P4502J2 (CYP2J2) 中等强度的混合抑制剂，其对 CYP2C8 和 CYP2J2 的 Ki 值分别为 4.82 μM 和 5.75 μM。
靶点

CYP2C8

4.82 μM (Ki)

CYP2J2

5.75 μM (Ki)
体外研究

Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K _i s of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF‑κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells.
体内研究

Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus.
化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于丹参。
用途丹酚酸C 1.具有明显的抗血小板聚集作用。2.自由基清除剂。
用途用于含量测定/鉴定/药理实验等。
药理药效:具有一定抗氧化、保护脑组织细胞损伤、保护心脑血管系统和抗HIV作用。