15D-PGJ2
15D-PGJ2 性质
| 闪点 | -9℃ |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 可溶于乙酸甲酯（提供预溶解 - 1mg/ml） |
| 形态 | 醋酸甲酯溶液 |
| 颜色 | 无色至浅黄 |
| InChI | 1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1 |
| InChIKey | VHRUMKCAEVRUBK-GODQJPCRSA-N |
| SMILES | CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O |
15D-PGJ2 用途与合成方法
|
PPARγ 2 μM (EC 50 ) |
PPARδ
|
Human Endogenous Metabolite
|
15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain.
安全信息
| 危险品标志 | F,Xi |
|---|---|
| 危险类别码 | 11-36/38-66-67-36 |
| 安全说明 | 16-26-29-33-36/37/39 |
| 危险品运输编号 | UN 1231 3/PG 2 |
| WGK Germany | 1 |
| 存储类别 | 3- 易燃液体 |
| 危险性类别 | 眼部刺激 类别2 易燃液体 类别2 特异性靶器官毒性-一次接触，类别3 |
15D-PGJ2 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-108568 | 15D-PGJ2 | 87893-55-8 | 1 mg (3.16 mM * 1 mL in Methyl acetate) | 3900 |
