2-Methyl-2-propan(ol-d)

clear colorless liquid

Tert-butyl Alcohol-OD is used as an organic solvent. Also it is used in the synthesis of proteosome inhibitors that are quite potent.

Labelled Tert-butyl Alcohol is used as an organic solvent. Also it is used in the synthesis of proteosome inhibitors that are quite potent.

Deuterated tert-butanol can be used in organic synthesis, such as the preparation of ,-dideuterated alcohols, and an example of its application is as follows: in a 10 mL single-necked flask protected by nitrogen, 95.1 mg (0.50 mmol) of Compound 1d was added, 2.5 mL of tetrahydrofuran, 187.8 mg (2.50 mmol) of deuterated tert-butanol (t-BuOD), a 51.7 mg (2.25 mmol) sodium block, stirred for 5 min at 0 C. Raise to room temperature and burst the reaction with 3.0 M aqueous hydrochloric acid. Extracted by adding ether with saturated saline, the organic phase was dried, concentrated and separated by column chromatography to give 37.3 mg of the target compound in 54% yield.