light yellow crystalline powder
2-Bromo-6-fluoronitrobenzene is a hydrocarbon derivative, mainly used as an organic intermediate.
The structure of 2-bromo-6-fluoronitrobenzene contains a nitro unit with high electron-withdrawing properties, which can easily undergo aromatic nucleophilic substitution reactions under the attack of common nucleophiles such as alcohols or amines.
To a suspension of sodium perborate tetrahydrate (135.374 g., 886.4 mmol) in 500 mL of acetic acid at 55C was added dropwise
2-bromo-6-fluoroaniline (33.685 g., 177.271 mmol) in 70 mL
solution in acetic acid. The reaction mixture was stirred at 55 C. for an additional 3 h. and then cooled in an ice bath to 0 C. Insoluble material was removed by filtration through a diatomaceous earth plug and washed with 100 mL of acetic acid. The combined acetic acid was added to 3 liters of ice water with stirring to give a waxy solid which was removed by filtration.
The crude solid was dissolved in 250 mL of ethyl acetate and washed three times with 200 mL of 10% aqueous hydrogen chloride, 200 mL of saturated sodium bicarbonate, and 100 mL of brine.
Concentrate the solution in vacuum to give 2-bromo-6-fluoronitrobenzene as a red oil in 11.51 g yield.
