DAMNACANTHOL

Damnacanthol is a natural product that can be isolated from Damnacanthus major[1]. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells[2].

15-LOX

[1] Ayyangar N R, et al. Anthraquinone and anthrone series—XXIII: The non-identity of 1: 3: 8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal. Tetrahedron, 1959, 6(4): 331-337.
[2] Dzoyem JP, et al. Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Macrophages and 15-LOX Activity by Anthraquinones from Pentas schimperi. Planta Med. 2016 Sep;82(14):1246-51. DOI:10.1055/s-0042-104417