32 g of salicylanilide was dissolved in 1000 ml of diethyl ether, 2 ml of
triethylamine and 25 ml of a 50% solution of methyl isocyanate in toluene
were added to the solution and the reaction mixture was allowed to stand
overnight at about 25°C. The resulting crystals of salicylanilide
methylcarbamate were removed by filtration, washed with 100 ml of diethyl
ether, and dried in vacuo to provide 37.5 g (92% yield) of salicylanilide
methylcarbamate having melting point of 160-161°C.
