DMP 777
DMP 777 性质
| 密度 | 1.227 |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO : 38.33 mg/mL (67.88 mM; 需要超声波)H2O : < 0.1 mg/mL (不溶) |
| 形态 | 粉末 |
| 酸度系数(pKa) | pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain) |
DMP 777 用途与合成方法
Human leukocyte elastase (HLE)
DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministeredwith omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats thatreceive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP-777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.
DMP 777 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-75957 | 1 mg | 681 | ||
| 2024-11-08 | HY-75957 | (2S)-N-[(1R)-1-(1,3-苯并二氧戊环-5-基)丁基]-3,3-二乙基-2-[4-[(4-甲基-1-哌嗪基)羰基]苯氧基]-4-氧代-1-氮杂环丁烷甲酰胺 | 157341-41-8 | 5mg | 1500 |
