[1,2,5]THIADIAZOLIDINE 1,1-DIOXIDE

144432-72-4

5823-51-8

General procedure for the synthesis of 1,2,5-thiadiazolidine 1,1-dioxide from 2-benzyl-1Λ~6~,2,5-thiadiazolidine-1,1-dione: A mixture of 2-benzyl-1,2,5-thiadiazolidine-1,1-dioxide (1.000 g, 4.7 mmol) with 20% palladium hydroxide (0.200 g) in methanol (20 mL) was placed under hydrogen atmosphere (1 atm) and stirred for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated to afford the white solid product 1,2,5-thiadiazolidine-1,1-dioxide (0.570 g, 99% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 6.68 (s, 2H), 3.30-3.25 (m, 4H).