In a reactor, 140 kg of N-(4-nitrophenylethyl)acetamide was dissolved in 190 kg of ethanol with constant stirring until complete dissolution. The pH of the reaction mixture was adjusted to 1 using 2 mol/L hydrochloric acid solution.Subsequently, the reaction mixture was heated to 80°C and maintained at this temperature for 20 hrs. Upon completion of the reaction, the reaction solution was cooled to room temperature to induce precipitation of the solid product. The crude product was purified by recrystallization through methanol, and after filtration and centrifugation, 116 kg of 4-nitrophenylethylamine hydrochloride was obtained, and the purity of the final product was 99.6%. The yield of this synthesis step was 84.7%.
