(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride

(alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

A mixture of (100 g) (R)-2-[2ˉ -(4-nitrophenyl)ethyl]amino] -1 -phenylethanol monohydroch bride (prepared according to example Ib), methanol (2000 mL) and Raney Nickel (20 g, wet) was stirred under hydrogen pressure (60 psi) for 6 hrs. The reaction solution was filtered, and the filtrate was concentrated in vacuo. The residue was mixed with isopropanol (300 mL) and reaction mixture was heated to 78C (à2). The mixture was added to toluene (900 mL). The reaction mixture was gradually cooled to 28C (à2) and stirred at this temperature for 3 hrs. The solid obtained was filtered, washed with toluene and dried under vacuo at 48C (à2) to obtain (R)-2-[[2-(4-aminophenyl)ethyl]-amino]- I -phenylethanol monohydrochioride.Yield: 78.1 g (86.1%); Purity by HPLC: 99.14 %.

[1] Patent: WO2015/44965, 2015, A1. Location in patent: Page/Page column 33; 34; 35; 36
[2] Patent: EP1440969, 2004, A1. Location in patent: Page 6
[3] Patent: EP1559427, 2005, A1. Location in patent: Page/Page column 6
[4] Patent: WO2014/132270, 2014, A2. Location in patent: Page/Page column 18-19
[5] Patent: WO2015/155664, 2015, A1. Location in patent: Page/Page column 19; 20