SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]
| Animal Model: | Male Sprague Dawley rats (250–360 g)[1] |
| Dosage: | 0.1~1 mg/kg |
| Administration: | I.p. |
| Result: | Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
|
| Animal Model: | Male Sprague Dawley rats (250–360 g)[1] |
| Dosage: | 1 mg/kg |
| Administration: | I.p. |
| Result: | Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.
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