TRAP-6 Peptide (trifluoroacetate salt)

TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC₅₀ = 0.8 μM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in anesthetized rats with a short decrease, an increase, and then a longer decrease in MAP following intravenous administration.

[1] R R VASSALLO. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.[J]. The Journal of Biological Chemistry, 1992, 267 9: 6081-6085.
[2] THOMAS SICKER. Systemic Vascular Effects of Thrombin and Thrombin Receptor Activating Peptide in Rats[J]. Thrombosis research, 2001, 101 6: Pages 467-475. DOI: 10.1016/s0049-3848(00)00429-1