C-Type Natriuretic Peptide-22 (human, porcine, rat) (trifluoroacetate salt)

C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.1,2,3 Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53.2 CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively).1 It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM).4,5 In vivo, CNP-22 (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.6WARNING This product is not for human or veterinary use.

[1] K J KOLLER  D V G. Molecular biology of the natriuretic peptides and their receptors.[J]. Circulation, 1992, 86 4: 1081-1088. DOI: 10.1161/01.cir.86.4.1081
[2] KULLO I, BURNETT J. C-Type Natriuretic Peptide[C]. 1900: 0. DOI: 10.1007/978-1-4612-0231-8_6
[3] KATERINA PEJCHALOVA  William R W  Pavel Krejci. C-natriuretic peptide: An important regulator of cartilage[J]. Molecular genetics and metabolism, 2007, 92 3: Pages 210-215. DOI: 10.1016/j.ymgme.2007.06.014
[4] J G DREWETT. Natriuretic peptide receptor-B (guanylyl cyclase-B) mediates C-type natriuretic peptide relaxation of precontracted rat aorta.[J]. The Journal of Biological Chemistry, 1995, 270 9: 4668-4674. DOI: 10.1074/jbc.270.9.4668
[5] YOSHIMASA MORI . Vasodilator effects of C-type natriuretic peptide on cerebral arterioles in rats[J]. European journal of pharmacology, 1997, 320 2: Pages 183-186. DOI: 10.1016/s0014-2999(96)00991-0
[6] GAN CHEN. C-type natriuretic peptide prevents kidney injury and attenuates oxidative and inflammatory responses in hemorrhagic shock[J]. Amino Acids, 2016, 49 2: 347-354. DOI: 10.1007/s00726-016-2367-0