Fmoc-N-amido-PEG24-acid contains an Fmoc-protected amine and a terminal carboxylic acid. The PEG spacer increases the aqueous solubility of the resulting compound. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond.
Fmoc-N-amido-PEG24-acid (CAS 2170484-59-8), also known as Fmoc-NH-PEG24-CH₂CH₂COOH, is a high-purity, heterogeneous bifunctional PEG derivative. It is primarily used in PROTAC synthesis, solid-phase peptide synthesis (SPPS), antibody-drug conjugates (ADCs) and targeted delivery systems.
