The reported synthesis methods for 1,1-Dimethoxy-2-(2-methoxyethoxy)ethane mainly use ethylene glycol monomethyl ether as the starting material and solvent, and with an appropriate strong base (sodium metal or sodium hydride), a strongly basic intermediate, sodium 2-methoxyethoxyethanol, is prepared by the Williamsom ether synthesis method. Then, it is reacted with the diol of haloacetaldehyde in a one-pot reaction to prepare 1,1-Dimethoxy-2-(2-methoxyethoxy)ethane.
1,1-Dimethoxy-2-(2-methoxyethoxy)ethane is used as a reactant in the synthesis of Dirithromycin (D493000) which is a semi-synthetic derivative of Erythromycin, an antibacterial agent.
